Author

Thomas Kremer

F. Hoffmann-La Roche AG

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Assay:imaging· 1 Organism:non-human primate· 1

Frequent Co-Authors

Solveig BadilloiD· 2 shared Annamaria Braendli-Baiocco· 1 shared Azad BonniiD· 1 shared Charlotte BoniD· 1 shared Christina A. MaatiD· 1 shared Claudia Milazzo· 1 shared Congwei WangiD· 1 shared Daniel Mona· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersNeuroscience

Solveig BadilloORCID

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Author profile →

3 papers

Recent·Most cited

UBE3A reinstatement restores behavior and proteome in an Angelman Syndrome mouse model of Imprinting Defects

Claudia Milazzo, Ramanathan Narayanan, Solveig Badillo, Silvia Wang, Rosaisela Almand, Edwin Mientjes, Stormy J. Chamberlain, Thomas Kremer, Ype Elgersma

This study shows that restoring UBE3A expression in a mouse model of Angelman Syndrome improves behavior and proteome, supporting UBE3A reinstatement as a therapeutic strategy.

bioRxiv · Sep 29, 2024 · PreprintNeuroscience

Angelman syndrome patient neuron screen identifies a potent and selective clinical ASO targeting UBE3A-ATS with long lasting effect in cynomolgus monkey

Ravi Jagasia, Charlotte Bon, Soren V. Rasmussen, Solveig Badillo, Disa Tehler, Danièle Buchy, Marco Berrera, Megana K. Prasad, Marco Terrigno, Nikhil Janak Pandya, Veronica Costa, Congwei Wang, Lykke Pedersen, Meghan T. Miller, Kamille Dumong Erichsen, , Marius Christian Hoener

The paper identifies a potent ASO targeting UBE3A-ATS in Angelman syndrome patient neurons, showing long-lasting effects in cynomolgus monkeys.

bioRxiv · Jun 9, 2022 · PreprintNeuroscience

Subcellular orchestration of alpha-synuclein variants in Parkinson’s disease brains revealed by 3D multicolor STED microscopy

Tim E. Moors, Christina A. Maat, Daniel Niedieker, Daniel Mona, Dennis Petersen, Evelien Huisman, Jeroen Kole, Samir F. El-Mashtoly, Liz Spycher, Wagner Zago, Robin Barbour, Olaf Mundigl, Klaus Kaluza, Sylwia Huber, Melanie N. Hug, , Wilma D. J. van de Berg

The paper uses 3D multicolor STED microscopy to study subcellular distribution of alpha-synuclein variants in Parkinson’s disease brains, revealing their association with pathology.

bioRxiv · Sep 17, 2019 · PreprintNeuroscience