Alma E. Martínez

Mimicking two posttranslational modifications associated with oxidative stress affords phase separation of vimentin

The paper shows that mimicking oxidative modifications at vimentin residues C328 and S49 induces phase separation, revealing a role for glycosylation and phosphorylation in regulating this process.

The pathogenic mutant vimentin L387P disrupts endoplasmic reticulum organization and proteostasis

The paper shows that the vimentin L387P mutation disrupts ER organization and proteostasis by forming aggregates that sequester degradation components and impair ER function.

Formation of vimentin biomolecular condensate-like structures under oxidative stress

This study shows that oxidative stress induces reversible vimentin filament remodeling into biomolecular condensate-like structures, potentially protecting cells from oxidative damage.