Effects of clinically relevant radionuclides on the activation of a type I interferon response by radiopharmaceuticals in syngeneic murine tumor models
Caroline P. Kerr, Julia Sheehan‐Klenk, Joseph J. Grudzinski, David P. Adam, Thanh Phuong T. Nguyen, C. de Aguiar Ferreira, Amber M. Bates, Won Jong Jin, Ohyun Kwon, Aeli P. Olson, Wilson Lin, Meredith Hyun, Justin C. Jagodinsky, Maria Powers, Raghava N. Sriramaneni, , Zachary Scott Morris
This study examines how different radionuclides affect the type I interferon response in tumor models and shows that 225Ac enhances immunotherapy response via STING-dependent mechanisms.
Cancer Immunology Research · May 29, 2025Peer-reviewedCancer Biology