Author

Joseph J. Grudzinski

University of Wisconsin–MadisonORCID 0000-0002-8799-1649Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2

Frequent Co-Authors

Amanda G. SheaiD· 2 shared Anatoly N. PinchukiD· 2 shared Bryan P. BednarziD· 2 shared C. de Aguiar FerreiraiD· 2 shared Caroline P. KerriD· 2 shared Christopher F. MasseyiD· 2 shared Cynthia ChoiiD· 2 shared Hansel Comas RojasiD· 2 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Amanda G. SheaORCID

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2 papers

Recent·Most cited

Priming versus propagating: distinct immune effects of an alpha- versus beta-particle emitting radiopharmaceutical when combined with immune checkpoint inhibition

Caroline P. Kerr, Won Jong Jin, Peng Liu, Joseph J. Grudzinski, Carolina A. Ferreira, Hansel Comas Rojas, Alejandro J. Oñate, Ohyun Kwon, Meredith Hyun, Malick Bio Idrissou, Rene Welch Schwartz, Jessica M. Vera, Paul A. Clark, Adedamola O. Adeniyi, Maya E. Takashima, , Zachary Scott Morris

This study compares the immune effects of alpha- and beta-particle emitting radiopharmaceuticals combined with immune checkpoint inhibitors in murine tumor models, finding distinct mechanisms of action based on radiation type.

Nature Communications · Jan 26, 2026Peer-reviewedCancer Biology

Effects of clinically relevant radionuclides on the activation of a type I interferon response by radiopharmaceuticals in syngeneic murine tumor models

Caroline P. Kerr, Julia Sheehan‐Klenk, Joseph J. Grudzinski, David P. Adam, Thanh Phuong T. Nguyen, C. de Aguiar Ferreira, Amber M. Bates, Won Jong Jin, Ohyun Kwon, Aeli P. Olson, Wilson Lin, Meredith Hyun, Justin C. Jagodinsky, Maria Powers, Raghava N. Sriramaneni, , Zachary Scott Morris

This study examines how different radionuclides affect the type I interferon response in tumor models and shows that 225Ac enhances immunotherapy response via STING-dependent mechanisms.

Cancer Immunology Research · May 29, 2025Peer-reviewedCancer Biology