Mechanisms of dexamethasone-induced bone toxicity in developing bone: a single-cell perspective
Kelly Warmink, Philip Lijnzaad, Stephanie A Schubert, Baojie Zhang, Tristan C.W. Vermaat, Lisa Jansen, Marloes C. C. van Gend, Aleksandra Balwierz, Natalie Proost, Marieke van de Ven, Johannes H. M. Merks, Thanasis Margaritis, Claudia Y. Janda
This study investigates dexamethasone-induced bone toxicity in developing bones using single-cell transcriptomics in mice, revealing reduced osteoblast and chondrocyte populations and disrupted B cell development.
JBMR Plus · Sep 3, 2025Peer-reviewedCancer Biology