Claudia Y. Janda

Cell surface proteomics of patient-derived malignant rhabdoid tumor organoids identifies ROBO1 as potential CAR T cell target for pediatric solid tumors.

Domain-resolved epitope mapping of B7-H3-targeting VHH-Fcs defines isoform-selective binders for antibody-drug conjugate development

The paper maps epitopes of B7-H3-targeting VHH-Fcs to identify isoform-selective binders for antibody-drug conjugate development.

Lineage-associated tumor cell states predict outcome and guide immunotherapeutic target selection in pediatric osteosarcoma

This study identifies lineage-associated tumor cell states in pediatric osteosarcoma that correlate with clinical outcomes and guide immunotherapeutic target selection.

A Dual-Pathway Wnt-IL-13 Fusion Protein Enhances Human Intestinal Regeneration Through Tuft Cell Activation

This paper develops a Wnt-IL-13 fusion protein that activates tuft cells to enhance intestinal regeneration in human organoids.

Mechanisms of dexamethasone-induced bone toxicity in developing bone: a single-cell perspective

This study investigates dexamethasone-induced bone toxicity in developing bones using single-cell transcriptomics in mice, revealing reduced osteoblast and chondrocyte populations and disrupted B cell development.

Integrin-activating Yersinia protein Invasin sustains long-term expansion of primary epithelial cells as 2D organoid sheets

The paper shows that Invasin-coated plates enable long-term 2D expansion of epithelial organoids from multiple species, offering an alternative to Matrigel/BME.