Douglas E. Weidemann

The paper establishes single-molecule RNA visualization in fission yeast using the MS2-MCP system by optimizing MCP expression and fluorescent tags.

The paper investigates how rhythmic RNA synthesis and degradation contribute to 24-hour and 12-hour RNA expression patterns in mouse fibroblasts, finding synthesis drives 24-hour rhythms and degradation drives 12-hour rhythms.

This study compares seven algorithms for detecting differential rhythmicity in transcriptomic data, finding high overlap in results but differences in output numbers and parameters.

The paper shows that some fission yeast cell division genes exhibit sub-Poissonian mRNA noise, below the classical Poissonian limit, due to specific transcription and degradation mechanisms.