Sarah Baxendale

Patient-specific zebrafish models reveal a complex phenotypic spectrum in NBAS-associated Atypical Osteogenesis Imperfecta

The paper uses zebrafish models to study NBAS variants in atypical Osteogenesis Imperfecta, showing different phenotypes based on variant type.

A dynein-driven nucleokinesis program enables neural crest migration through confined tissues in vivo

This study identifies a dynein-driven microtubule-based mechanism for nuclear translocation in zebrafish neural crest cells during confined migration.

Origami: Single-cell oriented 3D shape dynamics of folding epithelia from fluorescence microscopy images

Origami computes oriented cell shape features in curved epithelia using fluorescence microscopy images, accurately identifying cell orientation in zebrafish embryos.

Bmper is required for morphogenesis of the anterior and posterior semicircular canal ducts in the developing zebrafish inner ear

This study shows that Bmper promotes BMP signaling during semicircular canal development in zebrafish, leading to duct truncations in mutants.

Olfactory rod cells: a rare cell type in the larval zebrafish olfactory epithelium with an actin-rich apical projection

The paper identifies a rare olfactory rod cell type in larval zebrafish with an actin-rich apical projection, distinct from known olfactory sensory neurons and other sensory cells.

Identification of compounds that rescue otic and myelination defects in the zebrafish adgrg6 (gpr126) mutant

The paper identifies 68 compounds that reduce versican b expression in zebrafish adgrg6 mutants and 41 that restore myelin basic protein gene expression, with 19 candidates potentially interacting directly with Adgrg6.

Anteroposterior patterning of the zebrafish ear through Fgf- and Hh-dependent regulation of hmx3a expression

The paper investigates how Fgf and Hh signaling regulate hmx3a expression to establish anteroposterior patterning in zebrafish ears and shows that hmx3a is necessary but not sufficient for ear duplication.