Mary C. Mullins

Modeling Epithelial Morphogenesis and Cell Rearrangement during Zebrafish Epiboly: Tissue Deformation, Cell-Cell Coupling, and the Mechanical Response to Stress

The paper develops an agent-based model of zebrafish epiboly to study force generation and tissue deformation during early development.

EpicTope: predicting and validating non-disruptive epitope tagging sites

EpicTope predicts and validates epitope tagging sites by analyzing structural and functional features, showing effectiveness in zebrafish proteins.

Acvr2b receptors dose-dependently regulate dorsoventral patterning, FOP ACVR1-R206H signaling, and limit BMP/Nodal signaling

Oocyte polarity is established independently of the Balbiani body

The paper shows that oocyte polarity can form without the Balbiani body, using zebrafish mutants where Buc protein and mRNA localization remain normal despite Bb failure.

Zebrafish armc9 mutant reveals a link between ARM-Type fold domain loss, inflammation, and spinal curvature

This study identifies a link between ARM-type fold domain loss in zebrafish Armc9, inflammation, and spinal curvature, suggesting a role in ciliary signaling and adolescent idiopathic scoliosis.

Identification of Fasnall as a therapeutically effective Complex I inhibitor

This study identifies Fasnall as a Complex I inhibitor that mimics FASN inhibition, showing anti-tumor effects without neurological side effects.

Maternal regulation of the vertebrate oocyte-to-egg transition

This paper identifies maternal-effect mutants in zebrafish that reveal molecular mechanisms controlling the oocyte-to-egg transition, focusing on yolk globule formation and protein processing.

Maternal regulation of the vertebrate egg-to-embryo transition

The paper identifies four zebrafish maternal-effect mutants affecting egg-to-embryo transition processes and discovers a novel conserved gene, krang, involved in cortical granule function during egg activation.

Reduced GS domain serine/threonine requirements of Fibrodysplasia Ossificans Progressiva mutant type I BMP receptor ACVR1 in the zebrafish

This study investigates how FOP mutant ACVR1 receptors in zebrafish have altered requirements for GS domain phosphorylation and signaling, revealing distinct mechanisms for ligand-dependent and -independent signaling.

Bmper is required for morphogenesis of the anterior and posterior semicircular canal ducts in the developing zebrafish inner ear

This study shows that Bmper promotes BMP signaling during semicircular canal development in zebrafish, leading to duct truncations in mutants.

Evaluation of BMP-mediated patterning in a 3D mathematical model of the zebrafish blastula embryo

The paper develops a 3D PDE model to simulate BMP signaling during zebrafish blastula development and evaluates its sensitivity to biophysical parameters.

The Hippo pathway effector Taz is required for cell fate specification and fertilization in zebrafish

This study identifies Taz as essential for micropylar cell specification and micropyle formation in zebrafish through genetic and molecular analysis.