Prodromal dysfunction of α5GABA-A receptor modulated hippocampal ripples in Alzheimer's disease
Marcia Hillary Ratner, Scott S. Downing, Ouyang Guo, KathrynAnn E. Odamah, Tara M. Stewart, Vidhya Kumaresan, R. Jonathan Robitsek, Weiming Xia, David H. Farb
This study shows that 5IA, a memory enhancer, affects hippocampal ripples in TgF344-AD rats, indicating early network dysfunction before AD pathology and memory issues.
bioRxiv · May 10, 2021 · PreprintNeuroscience