The paper finds that ApoE ε4-dependent changes in CXCR3+CD127+ CD4+ T cells in peripheral blood correlate with elevated neurofilament light chain in Alzheimer's disease.

Journal of Alzheimer s Disease · Mar 20, 2025Peer-reviewedImmunology

Alzheimer Disease Heterogeneity Explained by Polygenic Risk Scores Derived from Brain Transcriptomic Profiles

Jaeyoon Chung, Nathan J Sahelijo, Toru Maruyama, Junming Hu, Rebecca Panitch, Weiming Xia, Jesse B Mez, Thor D. Stein, the Alzheimer's Disease Neuroimaging Initiative, Andrew J. Saykin, Haruko Takeyama, Lindsay A. Farrer, Paul K. Crane, Kwangsik T. Nho, Gyungah Jun

This study uses polygenic risk scores derived from brain transcriptomic profiles to explain clinical heterogeneity in Alzheimer's disease.

Alzheimer s & Dementia · May 11, 2023Peer-reviewedGenetic & Genomic Medicine

Accumulation of m6A exhibits stronger correlation with MAPT than beta-amyloid pathology in an APP NL-G-F /MAPT P301S mouse model of Alzheimer's disease

Lulu Jiang, Rebecca Roberts, Melissa Wong, Lushuang Zhang, Chelsea Joy Webber, Alper Kilci, Matthew Jenkins, Guangxin Sun, Sherif Rashad, Jingjing Sun, Peter C. Dedon, Sarah Anne Daley, Weiming Xia, Alejandro Nico Rondón-Ortiz, Luke Dorrian, , Benjamin L. Wolozin

This study shows that m6A accumulation correlates more strongly with MAPT pathology than beta-amyloid in an Alzheimer's mouse model.

bioRxiv · Mar 28, 2023 · PreprintNeuroscience

Protein phosphatase 2A, complement component 4, and APOE genotype linked to Alzheimer disease using a systems biology approach

Gyungah Jun, Yang You, Congcong Zhu, Gaoyuan Meng, Jaeyoon Chung, Rebecca Panitch, Junming Hu, Weiming Xia, David Alan Bennett, Tatiana Foroud, Weixin Wang, Jonathan L. Haines, Richard P Mayeux, Margaret Ann Pericak‐Vance, Gerard D. Schellenberg, , Lindsay A. Farrer

This paper identifies PPP2CB and C4B as key genes linked to Alzheimer's disease through a systems biology approach, showing their association with tau pathology and complement pathway activation.

Alzheimer s & Dementia · Feb 9, 2022Peer-reviewedGenetic & Genomic Medicine

Integrative Brain Transcriptome Analysis Links Complement Component 4 and HSPA2 to the APOE ε2 Protective Effect in Alzheimer Disease

Rebecca Panitch, Junming Hu, Jaeyoon Chung, Congcong Zhu, Gaoyuan Meng, Weiming Xia, David Alan Bennett, Kathryn L. Lunetta, Tsuneya Ikezu, Rhoda Au, Thor D. Stein, Lindsay A. Farrer, Gyungah Jun

The paper identifies a co-expression network involving C4A, C4B, and HSPA2 linked to APOE ε2's protective effect against Alzheimer's disease, primarily associated with tau pathology.

Molecular Psychiatry · Sep 3, 2021Peer-reviewedGenetic & Genomic Medicine

Prodromal dysfunction of α5GABA-A receptor modulated hippocampal ripples in Alzheimer's disease

Marcia Hillary Ratner, Scott S. Downing, Ouyang Guo, KathrynAnn E. Odamah, Tara M. Stewart, Vidhya Kumaresan, R. Jonathan Robitsek, Weiming Xia, David H. Farb

This study shows that 5IA, a memory enhancer, affects hippocampal ripples in TgF344-AD rats, indicating early network dysfunction before AD pathology and memory issues.

bioRxiv · May 10, 2021 · PreprintNeuroscience