This paper evaluates BM-MSC-based therapies for POI in preclinical models, finding improvements in estradiol, anti-Mullerian hormone, and reproductive outcomes.

bioRxiv · Jul 3, 2026 · PreprintCell Biology

Protein language models accelerate the discovery of Plastic-Degrading Enzymes

David Medina-Ortiz, Diego Álvarez-Saravia, Nicole Soto-García, Diego Sandoval Vargas, Jacqueline Aldridge, Sebastián Rodríguez, Bárbara A. Andrews, Juan A. Asenjo, Anamaria Sanchez–Daza

This paper uses AI to discover and design plastic-degrading enzymes, achieving 89% accuracy in classification and generating new enzyme sequences with improved properties for PET degradation.

bioRxiv · Feb 9, 2025 · PreprintBioengineering

Peptipedia v2.0: A peptide sequence database and user-friendly web platform. A major update

Gabriel Cabas-Mora, Anamaria Sanchez–Daza, Nicole Soto-García, Valentina Garrido, Diego Álvarez-Saravia, Marcelo A. Navarrete, Lindybeth Sarmiento Varón, Julieta Sepúlveda-Yáñez, Mehdi D. Davari, Frédéric Cadet, Álvaro Olivera‐Nappa, Roberto Uribe-Paredes, David Medina-Ortiz

Peptipedia v2.0 expands its peptide database by 45% and integrates machine learning models to annotate peptide sequences with biological activities.

Database · Jan 1, 2024Peer-reviewedBioinformatics