Salmonella SteD and mammalian SUSD6 use TMEM127 to co-disinhibit the WWP2 E3 ubiquitin ligase
Samkeliso V. Blundell, Mei Liu, Romina Tocci, Andrea Majstorović, Solène Tsang, David W. Holden
The paper shows that TMEM127 and SUSD6, along with Salmonella SteD, co-disinhibit WWP2 E3 ubiquitin ligase through distinct mechanisms.
bioRxiv · Apr 23, 2025 · PreprintCell Biology