Author

Mengkai Zhang

Shenzhen UniversityORCID 0000-0002-6778-2022Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Research Focus:perturbation response prediction· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Kai WuiD· 1 shared Mengyu Shang· 1 shared Shang WangiD· 1 shared Weiren HuangiD· 1 shared Xianteng WangiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

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1 shared paperMolecular Biology

Kai WuORCID

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1 paper

Recent·Most cited

Molecular BiologybioRxivPreprintOct 16, 2026

Splicing-guaranteed artificial introns enable efficient homology-directed repair at internal exons and streamlined cell engineering

Shang Wang, Xianteng Wang, Mengyu Shang…·Weiren Huang

This paper introduces ARI-HDR, a method for efficient internal-exon editing using splicing-guaranteed artificial introns, achieving over 80% editing efficiency in human genes.

DOI 10.64898/2026.10.16.759525

humanCRISPR screen

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