Author

Atli Thorarensen

Pfizer (United States)ORCID 0000-0002-6791-5809Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

Akshay Salegaonkar· 1 shared Alejandra Macias-GarciaiD· 1 shared Alpay Dermenci· 1 shared Andrew C. FlickiD· 1 shared Anthony Monti· 1 shared Barbara J. HoganiD· 1 shared Brian S. GerstenbergeriD· 1 shared Cameron C. TrenoriD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperMolecular Biology

Akshay Salegaonkar

Mutual co-authors in cluster

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2 papers

Recent·Most cited

DCN1 inhibitor induces fetal hemoglobin through self-limited regulation of CUL3 neddylation

Samuel A. Miller, Anthony Monti, Enhua H. Zhou, Chi Hua Sarah Lin, Orna Lynch, Sayani Mukherjee, Cassie Hei, Robert Nicewonger, Colin Diner, Alejandra Macias-Garcia, Kristen A. Marino, Na Li, Ravi K. Ujjinamatada, Akshay Salegaonkar, Sunil Kuppasani, , Sriram Krishnamoorthy

The paper identifies DCN1 as a therapeutic target for beta-hemoglobinopathies by showing its inhibition increases fetal hemoglobin through selective chromatin changes without cytotoxicity.

bioRxiv · Apr 24, 2026 · PreprintMolecular Biology

Structural basis for CCR6 modulation by allosteric antagonists

David Jon Wasilko, Brian S. Gerstenberger, Kathleen A. Farley, Wěi Li, Jennifer Alley, Mark E. Schnute, Ray J. Unwalla, Jorge Victorino, Kimberly K. Crouse, Ru Ding, Parag V. Sahasrabudhe, Fabien Vincent, Richard K. Frisbie, Alpay Dermenci, Andrew C. Flick, , Huixian Wu

This paper presents two inactive CCR6 structures bound to allosteric antagonists, revealing structural insights into CCR6 inhibition and its implications for drug discovery.

Nature Communications · Aug 31, 2024Peer-reviewedBiochemistry