Structural basis for CCR6 modulation by allosteric antagonists
David Jon Wasilko, Brian S. Gerstenberger, Kathleen A. Farley, Wěi Li, Jennifer Alley, Mark E. Schnute, Ray J. Unwalla, Jorge Victorino, Kimberly K. Crouse, Ru Ding, Parag V. Sahasrabudhe, Fabien Vincent, Richard K. Frisbie, Alpay Dermenci, Andrew C. Flick, , Huixian Wu
This paper presents two inactive CCR6 structures bound to allosteric antagonists, revealing structural insights into CCR6 inhibition and its implications for drug discovery.
Nature Communications · Aug 31, 2024Peer-reviewedBiochemistry