John S. DePaolo

This study evaluates polygenic risk scores for hernia susceptibility and finds they are associated with incisional hernia but do not improve clinical risk prediction beyond traditional factors.

This study identifies 243 genome-wide significant loci for hernia subtypes, reveals shared and distinct genetic factors, and identifies potential therapeutic targets.

This study creates a gene regulation map of the human fetal heart to interpret genetic variants associated with congenital heart disease and cardiac traits, identifying valvular interstitial cells as key regulators.

This study evaluates the reliability of coronary artery disease polygenic risk scores across diverse populations, finding poor individual agreement despite equivalent population-level performance.