A post-mitotic bistable switch actively safeguards mature neurons against reciprocal transdifferentiation in vivo
Q Chen, Yineng Xu, Bei Wang, Yifan Shen, Sasidhar Karuparti, Nambita S Sahai, Chun Han
The paper shows that mature neurons use a bistable switch to prevent transdifferentiation, with conserved mechanisms in Drosophila and humans.
bioRxiv · Jun 22, 2026 · PreprintDevelopmental Biology