Chun Han

This study shows that Orion's presentation via glycosaminoglycans regulates distinct glial responses during Drosophila neuronal pruning.

The paper shows that mature neurons use a bistable switch to prevent transdifferentiation, with conserved mechanisms in Drosophila and humans.

This paper introduces nickase-based MAGIC as a safer alternative to DSB-based CRISPR/Cas9 for generating genetic mosaics in Drosophila, showing that single-strand nicks can induce recombination with tunable efficiency.

The paper introduces a genome-wide gRNA-marker kit for MAGIC in Drosophila, enabling clonal analysis of previously inaccessible genetic elements and tissues.

This paper develops a toolkit using AcrIIA4 to suppress, subtract, and segregate Cas9 activity in Drosophila for more precise CRISPR applications.

This study shows that polyploidy, induced by Notch signaling, enables epithelial cells to become non-professional phagocytes during stress, facilitating phagocytic functions essential for tissue homeostasis.

This study shows that the Drosophila ABCA protein Eato regulates neurodegeneration by opposing roles in neurons and phagocytes, affecting phagocytosis through suppression of phosphatidylserine signals.

The paper investigates how the Pickpocket ion channel is trafficked to dendrites in Drosophila sensory neurons and finds that its delivery is coordinated with dendrite growth.

The paper introduces OptoTrap, a light-inducible system for manipulating endogenous proteins, and uses it to study microtubule and kinesin-1 roles in dendrite patterning in Drosophila sensory neurons.

The paper develops a CRISPR toolkit for tissue-specific gene knockout in Drosophila motor neurons, muscles, and glial cells, revealing ESCRT's role in NMJ extracellular vesicle formation.

This study identifies Orion as a bridging molecule that connects phosphatidylserine and Draper in Drosophila phagocytosis of degenerating neurons, revealing a conserved mechanism.

The paper presents a genetic toolkit to convert Gal4 strains into LexA and Flippase transgenes using genetic crosses and fluorescence screening, demonstrating its effectiveness with ten Gal4 lines.

The paper improves CRISPR/Cas9 tools for tissue-specific mutagenesis in Drosophila by enhancing gRNA efficiency, enabling cell labeling, and providing genetic reagents for flexible Cas9 deployment.

The paper introduces MAGIC, a CRISPR/Cas9-based method to generate mosaic animals in Drosophila by inducing DNA double-strand breaks, enabling efficient gene function studies and fluorescent clone generation.

The paper shows that low FoxO expression in Drosophila somatosensory neurons allows dendrite overgrowth under nutrient restriction, providing a survival advantage.

This paper introduces CRISPR-TRiM, a method for tissue-specific gene knockout in Drosophila, showing it can reveal redundant gene functions in neuronal development.