Author

Julián Sevilla

Centre for Biomedical Network Research on Rare DiseasesORCID 0000-0002-6852-1860Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Josune ZubicarayiD· 2 shared Susana NavarroiD· 2 shared Alicia Martínez‐LópeziD· 1 shared Amaia Vilas‐ZornozaiD· 1 shared Andrés JereziD· 1 shared Asier Ullate‐AgoteiD· 1 shared Beatriz Fernández-VarasiD· 1 shared Cristina BeléndeziD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersImmunology

Josune ZubicarayORCID

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3 papers

Recent·Most cited

ImmunologybioRxivPreprintFeb 20, 2025

Inhibition of NLRP1 Inflammasome Activation by Tyrosine Kinase Inhibitors Restores Erythropoiesis in Diamond-Blackfan Anemia Syndrome

Juan M. Lozano Gil, Lola Rodríguez‐Ruiz, Manuel Palacios…·Víctoriano Mulero

This study shows that tyrosine kinase inhibitors can restore erythropoiesis in Diamond-Blackfan Anemia by inhibiting NLRP1 inflammasome activation.

1 citation

Genetic & Genomic MedicineHaematologicaPeer-reviewedApr 6, 2023

Gene Therapy Restores the Transcriptional Program of Hematopoietic Stem Cells in Fanconi Anemia

Miren Lasaga, Paula Rı́o, Amaia Vilas‐Zornoza…·Juan Antonio Bueren

This study shows gene therapy can restore the transcriptional program of hematopoietic stem cells in Fanconi Anemia patients, making them resemble healthy donor cells.

16 citations

Molecular BiologyPLoS ONEPeer-reviewedMay 9, 2019

Splice donor site sgRNAs enhance CRISPR/Cas9-mediated knockout efficiency

Ignacio García‐Tuñón, Verónica Alonso-Pérez, Elena Vuelta…·Manuel Sánchez‐Martín

This study shows that targeting splice donor sites with sgRNAs improves CRISPR/Cas9 knockout efficiency by increasing frameshift mutations and disrupting pre-mRNA splicing.

26 citations

CRISPR screenexperimental assay