3D Reconstruction of Nanoparticle Distribution in Tumor Spheroids with Volume Electron Microscopy
Davide Bottone, Lukas R. H. Gerken, Sebastian F. M. Habermann, José Marı́a Mateos, Miriam S. Lucas, Johannes Riemann, Melanie Fachet, Ute Resch‐Genger, Vera Maria Kissling, Matthias Roesslein, Alexander Gogos, Inge Katrin Herrmann
The paper presents an end-to-end pipeline for segmenting nanoparticles and cellular structures in 3D electron microscopy data of tumor spheroids, revealing preferential NP clustering near nuclei.
Small · Oct 27, 2026Peer-reviewedBioinformatics