Author

Lukas R. H. Gerken

EmpaORCID 0000-0002-8568-2674Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Bioinformatics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:electronic health records· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

Alexander GogosiD· 3 shared Inge Katrin HerrmanniD· 3 shared Sebastian F. M. HabermanniD· 3 shared Vera Maria KisslingiD· 2 shared Christian Monachon· 1 shared Davide BottoneiD· 1 shared Johannes RiemanniD· 1 shared José Marı́a MateosiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersBioinformatics

Alexander GogosORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

3D Reconstruction of Nanoparticle Distribution in Tumor Spheroids with Volume Electron Microscopy

Davide Bottone, Lukas R. H. Gerken, Sebastian F. M. Habermann, José Marı́a Mateos, Miriam S. Lucas, Johannes Riemann, Melanie Fachet, Ute Resch‐Genger, Vera Maria Kissling, Matthias Roesslein, Alexander Gogos, Inge Katrin Herrmann

The paper presents an end-to-end pipeline for segmenting nanoparticles and cellular structures in 3D electron microscopy data of tumor spheroids, revealing preferential NP clustering near nuclei.

Small · Oct 27, 2026Peer-reviewedBioinformatics

Nanoparticle Metal Mass Uptake Governs Radiosensitizing Efficacy Across 2D, 3D, and In Vivo Models

Lukas R. H. Gerken, Laurin G.S. Schaller, Rüveyda Dok, Selina Camenisch, Alexander Gogos, Sebastian F. M. Habermann, Sandra Nuyts, Inge Katrin Herrmann

This study develops a 3D spheroid model of head and neck cancer to evaluate nanoparticle radiosensitization across 2D, 3D, and in vivo settings, finding consistent effects when nanoparticle mass uptake is matched.

bioRxiv · Aug 13, 2025 · PreprintCancer Biology

Cathodoluminescent and Characteristic X-ray-emissive Rare-Earth-doped Core/Shell Immunolabels for Spectromicroscopic Analysis of Cell Surface Receptors

Sebastian Habermann, Lukas R. H. Gerken, Mathieu Kociak, Christian Monachon, Vera Maria Kissling, Alexander Gogos, Inge Katrin Herrmann

This paper introduces rare-earth-doped core/shell nanoparticles for spectromicroscopic analysis of cell surface receptors using cathodoluminescence and X-ray emission.

Small · Sep 9, 2024Peer-reviewedBioengineering