John David Carpten

This study uses single-cell whole genome sequencing and spatial transcriptomics to uncover intra-tumoral heterogeneity in ovarian cancer, revealing evolutionary relationships and functionally consequential copy number alterations.

This study examines epigenetic, microbiome, and immune differences in early-onset colorectal cancer (EOCRC) compared to average-onset CRC, finding accelerated epigenetic aging and stronger immune-microbe correlations in EOCRC.

This study identifies distinct molecular features of early-onset colorectal cancer in Hispanic/Latino patients through multi-omics analysis, revealing significant WNT pathway alterations and potential therapeutic targets.

This study profiles colorectal cancer in Hispanic/Latino patients, finding high genetic similarity to Peruvians-from-Lima-like populations and identifying key mutations and pathways associated with young-onset disease.

The paper identifies genomic subtypes of multiple myeloma using the MMRF CoMMpass study and finds that 25.5% of patients transition to a high-risk expression subtype at progression, which expresses immunotherapy targets.

The paper uses single-cell sequencing of genomic DNA to resolve sub-clonal heterogeneity in the COLO829 cell line, identifying four major sub-clones and explaining conflicting bulk sequencing results.