Ajai Chari

Structure-guided engineering of CCL27 enhances natural ligand CAR T-cells against CCR10 for multiple myeloma

This paper engineers CCL27 mutants to enhance CAR T-cell efficacy against multiple myeloma by targeting CCR10, achieving results comparable to BCMA CAR-Ts.

Targeting high-risk multiple myeloma genotypes with optimized anti-CD70 CAR-T cells

Structure-optimized CD27-based CAR-T cells targeting CD70 show >80-fold improved expansion in vivo and offer a potential therapy for high-risk multiple myeloma patients.

A three gene signature predicts response to selinexor in multiple myeloma

The paper identifies a three-gene expression signature that predicts response to selinexor in multiple myeloma and glioblastoma.

Genomic Basis of Multiple Myeloma Subtypes from the MMRF CoMMpass Study

The paper identifies genomic subtypes of multiple myeloma using the MMRF CoMMpass study and finds that 25.5% of patients transition to a high-risk expression subtype at progression, which expresses immunotherapy targets.