Author

Cong‐Zhao Zhou

University of Science and Technology of ChinaORCID 0000-0002-6881-7151Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 1 Research Focus:benchmarking· 1 Approach:deep learning· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Approach:large language model· 1 Assay:protein sequence· 1 Research Focus:sequence-to-function modeling· 1

Frequent Co-Authors

Shu‐Jing HaniD· 2 shared Yuxing CheniD· 2 shared Bo WangiD· 1 shared Enhong CheniD· 1 shared Feng YangiD· 1 shared Hao WangiD· 1 shared Heng-Rui ZhaoiD· 1 shared Houqiang LiiD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBioinformatics

Shu‐Jing HanORCID

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2 papers

Recent·Most cited

Integration of protein and coding sequences enables mutual augmentation of the language model

Heng-Rui Zhao, Meng‐Ting Cheng, Zhu Jinhua, Hao Wang, Xiang-Rui Yang, Bo Wang, Yuanxin Sun, Ming-Hao Fang, Enhong Chen, Houqiang Li, Shu‐Jing Han, Yuxing Chen, Cong‐Zhao Zhou

This paper introduces a dual-language foundation model that integrates protein and coding sequences, showing improved performance in discriminative tasks and generating coding sequences with higher protein yield.

bioRxiv · Oct 24, 2024 · PreprintBioinformatics

DNA looping mediates cooperative transcription activation

Shu‐Jing Han, Yong‐Liang Jiang, Linlin You, Li-Qiang Shen, Xiaoxian Wu, Feng Yang, Ning Cui, Wen-Wen Kong, Hui Sun, Ke Zhou, Hui-Chao Meng, Zhipeng Chen, Yuxing Chen, Yu Zhang, Cong‐Zhao Zhou

The paper reports cryo-EM structures of bacterial transcription activation complexes and proposes a DNA looping mechanism for cooperative transcription activation.

Nature Structural & Molecular Biology · Jan 4, 2024Peer-reviewedMolecular Biology