Author

Linlin You

Chinese Academy of SciencesORCID 0000-0002-6539-5889Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:E. coli· 2 Organism:bacteria (other)· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

Chengyuan WangiD· 2 shared Jason T. KaelberiD· 2 shared Konstantin D. KuznedeloviD· 2 shared Richard H. EbrightiD· 2 shared Vadim MolodtsoviD· 2 shared Xiaoxian WuiD· 2 shared Yu ZhangiD· 2 shared Aijia Wen· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersMolecular Biology

Chengyuan WangORCID

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4 papers

Recent·Most cited

Structural basis of long-range transcription-translation coupling

Chengyuan Wang, Vadim Molodtsov, Shashank Shandilya, Linlin You, Jing Zhang, Konstantin Kuznedelov, Bryce E. Nickels, Jason T. Kaelber, Gregor Blaha, Richard H. Ebright

The paper reports structures of long-range coupled transcription-translation complexes (TTC-LC) in E. coli, showing how they differ from TTC-B and their roles in transcription-translation coupling.

Proceedings of the National Academy of Sciences · Jun 10, 2026Peer-reviewedMolecular Biology

Structural basis of archaeal FttA-dependent transcription termination

Linlin You, Chengyuan Wang, Vadim Molodtsov, Konstantin D. Kuznedelov, Xinyi Miao, Breanna R. Wenck, Paul Ulisse, Travis J. Sanders, Craig J. Marshall, Emre Firlar, Jason T. Kaelber, Thomas J. Santangelo, Richard H. Ebright

The paper reports the structure of the archaeal FttA pre-termination complex using cryo-EM, revealing its mechanism of action and functional homology with bacterial and eukaryotic systems.

Nature · Sep 25, 2024Peer-reviewedMolecular Biology

DNA looping mediates cooperative transcription activation

Shu‐Jing Han, Yong‐Liang Jiang, Linlin You, Li-Qiang Shen, Xiaoxian Wu, Feng Yang, Ning Cui, Wen-Wen Kong, Hui Sun, Ke Zhou, Hui-Chao Meng, Zhipeng Chen, Yuxing Chen, Yu Zhang, Cong‐Zhao Zhou

The paper reports cryo-EM structures of bacterial transcription activation complexes and proposes a DNA looping mechanism for cooperative transcription activation.

Nature Structural & Molecular Biology · Jan 4, 2024Peer-reviewedMolecular Biology

Structural basis for intrinsic transcription termination

Linlin You, Expery O. Omollo, Chengzhi Yu, Rachel Anne Mooney, Jing Shi, Liqiang Shen, Xiaoxian Wu, Aijia Wen, Dingwei He, Yuan Zeng, Yu Feng, Robert C. Landick, Yu Zhang

The paper reports cryo-EM structures of E. coli intrinsic termination complexes to define the structural mechanism of bacterial transcription termination.

Nature · Jan 11, 2023Peer-reviewedMolecular Biology