Yu Zhang

The paper reports cryo-EM structures of bacterial transcription activation complexes and proposes a DNA looping mechanism for cooperative transcription activation.

The paper reports cryo-EM structures of E. coli intrinsic termination complexes to define the structural mechanism of bacterial transcription termination.

This study investigates reiterative transcription initiation, showing RNA extension occurs without DNA scrunching, involves a short RNA-DNA hybrid, and uses an alternative RNA exit pathway.

This paper discovers pseudouridimycin, a novel antibacterial compound that inhibits bacterial RNA polymerase and shows potent activity against drug-resistant pathogens.

This study reports crystal structures of Mycobacterium tuberculosis RNA polymerase with and without antituberculosis drugs, revealing a new class of inhibitors and their binding mechanisms.