The CryoEM Structure of Human GPR75: Insights into ECL2-Mediated Activation
A. Manuel Liaci, Vasudha Gathey, Aniket Magarkar, Tobias Kiechle, Camilla Mayer, Giuseppe Bruschetta, Jürgen Schymeinsky, Curtis R. Warren, Herbert Nar, Rebecca Ebenhoch
The paper presents the cryoEM structure of unliganded human GPR75 and functional data showing its active-like state and signaling properties.
bioRxiv · Jul 30, 2025 · PreprintBiochemistry