Author

Lin‐Yun Liu

Fudan UniversityORCID 0000-0002-6902-759XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Assay:electronic health records· 2 Approach:experimental assay· 2 Organism:mouse· 2 Organism:human· 1 Approach:machine learning (classical)· 1 Research Focus:variant effect prediction· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Yinghui FuiD· 3 shared Yong‐Chun YuiD· 3 shared Shuqing ZhangiD· 2 shared Changzheng WangiD· 1 shared Guang‐Zhong WangiD· 1 shared Jian MaiD· 1 shared Jun-Wei CaoiD· 1 shared Ke FaniD· 1 shared

Activity by Year

2017-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersNeuroscience

Yinghui FuORCID

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3 papers

Recent·Most cited

MvPPT: a highly efficient and sensitive pathogenicity prediction tool for missense variants

Shiyuan Tong, Ke Fan, Zaiwei Zhou, Lin‐Yun Liu, Shuqing Zhang, Yinghui Fu, Guang‐Zhong Wang, Ying Zhu, Yong‐Chun Yu

The paper introduces mvPPT, a missense variant pathogenicity predictor that outperforms existing tools in sensitivity and accuracy using gradient boosting and diverse feature sets.

Genomics Proteomics & Bioinformatics · Aug 5, 2022Peer-reviewedBioinformatics

Early-generated interneurons regulate neuronal circuit formation during early postnatal development

Changzheng Wang, Jian Ma, Shao-Na Jiang, Tian-Qi Chen, Ye-Qian Xu, Zu-Liang Yuan, Xiaoyi Mao, Shuqing Zhang, Lin‐Yun Liu, Yinghui Fu, Yong‐Chun Yu

This study shows that early-generated interneurons (EGIns) have more mature properties and significantly influence network synchronization and inhibitory synaptic transmission during early postnatal development.

eLife · May 23, 2019Peer-reviewedNeuroscience

Eye opening differentially modulates inhibitory synaptic transmission in the developing visual cortex

Wuqiang Guan, Jun-Wei Cao, Lin‐Yun Liu, Zhihao Zhao, Yinghui Fu, Yong‐Chun Yu

This study shows eye opening modulates inhibitory synaptic transmission in the mouse visual cortex by differentially affecting uIPSCs from SST-INs and FS-INs.

eLife · Dec 11, 2017Peer-reviewedNeuroscience