This study shows dynorphin modulates motivation via a pallido-amygdala cholinergic circuit by both disinhibiting and autoinhibiting cholinergic transmission in mice.

bioRxiv · Jul 31, 2024 · PreprintNeuroscience

Cell-type-specific striatal modulation of amygdalar acetylcholine in salience assignment

Aixiao Chen, Yunjing Li, Hangfei Zhu, Hanmei Gu, Yanhong Weng, Qinyong Ye, Wuqiang Guan, Qingtao Sun, Bo Li, Fuqiang Xu, Hanfei Deng, Xiong Xiao

The paper shows striatal D1 and D2 MSNs regulate BLA ACh levels, influencing salience assignment through distinct mechanisms.

bioRxiv · Jul 30, 2024 · PreprintNeuroscience

Specific and comprehensive genetic targeting reveals brain-wide distribution and synaptic input patterns of GABAergic axo-axonic interneurons

Ricardo Raudales, Gukhan Kim, Sean M. Kelly, Joshua T. Hatfield, Wuqiang Guan, Shengli Zhao, Anirban Paul, Yongjun Qian, Bo Li, Z. Josh Huang

eLife · Jan 17, 2024Peer-reviewedNeuroscience

A fluorescent sensor for spatiotemporally resolved endocannabinoid dynamics in vitro and in vivo

Ao Dong, Kaikai He, Barna Dudok, Jordan S. Farrell, Wuqiang Guan, Daniel J. Liput, Henry L. Puhl, Ruyi Cai, Huan Wang, Jiali Duan, Eddy Albarran, Jun Ding, David M. Lovinger, Bo Li, Iván Soltész, Yulong Li

The paper introduces a genetically encoded fluorescent sensor, GRABeCB2.0, to measure endocannabinoid dynamics with high spatiotemporal resolution in vitro and in vivo, revealing new insights into eCB signaling in neurons and brain regions.

Nature Biotechnology · Nov 11, 2021Peer-reviewedNeuroscience

Eye opening differentially modulates inhibitory synaptic transmission in the developing visual cortex

Wuqiang Guan, Jun-Wei Cao, Lin‐Yun Liu, Zhihao Zhao, Yinghui Fu, Yong‐Chun Yu

This study shows eye opening modulates inhibitory synaptic transmission in the mouse visual cortex by differentially affecting uIPSCs from SST-INs and FS-INs.

eLife · Dec 11, 2017Peer-reviewedNeuroscience