A multiplexed bioluminescent reporter for sensitive and non-invasive tracking of DNA double strand break repair dynamics in vitro and in vivo
Jasper Che-Yung Chien, Elie I. Tabet, Kelsey Pinkham, Cintia Carla da Hora, Jason Cheng-Yu Chang, Steven Lin, Christian E. Badr, Charles Pin‐Kuang Lai
This paper introduces a bioluminescent reporter system to track DNA double strand break repair dynamics in vitro and in vivo, showing high correlation with sequencing data and revealing new insights into repair mechanisms and drug effects.
Nucleic Acids Research · Jul 31, 2020Peer-reviewedGenetics