Steven Lin

The paper reports cryo-EM structures of the human 26S proteasome bound to K11/K48-branched ubiquitin chains, revealing a multivalent recognition mechanism involving new binding sites for K11 and alternating K11-K48 linkages.

This paper develops a robust platform for producing BaEVRless-lentiviral vectors for transducing primary natural killer cells by optimizing production in ASCT2-KO HEK293T cells.

The paper describes a method for efficient targeted DNA insertion in plant genomes using CRISPR-Cas9 and single-stranded DNA oligonucleotides without requiring expensive equipment or chemical modifications.

This paper introduces a bioluminescent reporter system to track DNA double strand break repair dynamics in vitro and in vivo, showing high correlation with sequencing data and revealing new insights into repair mechanisms and drug effects.