Christian E. Badr

Integrated single-cell profiling of RNA and DNA interactomes reveals targetable chromatin architectures in cancer

The paper introduces SCIENCE-seq, a single-cell interactomics platform that maps RNA-RNA and DNA-DNA interactions in cancer, identifying therapeutic targets through chromatin architectures.

SCD1 and SCD5 Modulate PARP-Dependent DNA Repair via Fatty Acid Desaturation in Glioblastoma

This study shows SCD1 and SCD5 modulate DNA repair in glioblastoma via fatty acid desaturation, with SCD5 specifically affecting sphingolipids and PARP1 activity.

Targeting SCD triggers lipotoxicity of cancer cells and enhances anti-tumor immunity in breast cancer brain metastasis mouse models

This study shows that inhibiting SCD in breast cancer brain metastases induces lipotoxicity and enhances anti-tumor immunity, improving survival in mouse models.

Multi-Region Brain Organoid: Fusion Organoid with Cerebral, Endothelial and Mid-Hindbrain Components

This paper introduces Multi-Region Brain Organoids (MRBOs) that integrate cerebral, mid/hindbrain, and complex endothelial components, revealing new roles for endothelial cells in brain development.

Expression-based selection identifies a microglia-tropic AAV capsid for direct and CSF routes of administration in mice

The paper identifies an AAV capsid, MC5, that efficiently and specifically transduces microglia via direct and intracerebroventricular injection in mice.

A multiplexed bioluminescent reporter for sensitive and non-invasive tracking of DNA double strand break repair dynamics in vitro and in vivo

This paper introduces a bioluminescent reporter system to track DNA double strand break repair dynamics in vitro and in vivo, showing high correlation with sequencing data and revealing new insights into repair mechanisms and drug effects.