This study identifies genetic comorbidities and potential biomarkers for Alzheimer's disease through pleiotropy analysis and functional network studies.

bioRxiv · Mar 5, 2024 · PreprintNeuroscience

Searching across-cohort relatives in 54,092 GWAS samples via encrypted genotype regression

Qi-Xin Zhang, Tianzi Liu, Xinxin Guo, Jianxin Zhen, Mengyuan Yang, Saber Khederzadeh, Fang Xiao Zhou, Xiaotong Han, Qiwen Zheng, Peilin Jia, Xiaohu Ding, Mingguang He, Xin Zou, Jia-Kai Liao, Hongxin Zhang, , Guo‐Bo Chen

This paper introduces encG-reg, an encrypted genotype regression method that identifies relatives across cohorts without sharing raw data, achieving accuracy comparable to traditional methods.

PLoS Genetics · Jan 11, 2024Peer-reviewedGenetics

Network-based hub biomarker discovery for glaucoma

Xueli Zhang, Shuo Ma, Xianwen Shang, Xiayin Zhang, Lingcong Kong, Jason James Ha, Yu Chuan Huang, Zhuoting Zhu, Shunming Liu, Katerina Kiburg, Danli Shi, Yueye Wang, Yining Bao, Hao Lai, Wei Wang, , Mingguang He

This paper identifies hub biomarkers and pathways for glaucoma using network medicine approaches and validates them with text-mining and genomic data.

bioRxiv · Oct 9, 2022 · PreprintBioinformatics