Guo‐Bo Chen

UK BioCoin: Swift Trait-Specific Summary Statistics Regression for UK Biobank

UK BioCoin enables trait-specific covariate adjustment for UK Biobank summary statistics without individual-level data, achieving high correlation with full GWAS results.

Analytical and computational solution for the estimation of SNP-heritability in biobank-scale and distributed datasets

This paper presents an analytical solution for estimating SNP-heritability in biobank-scale and distributed datasets, achieving high precision and efficiency.

Rapid and accurate multi-phenotype imputation for millions of individuals

The paper introduces PIXANT, a multi-phenotype imputation method that improves GWAS power by imputing 425 phenotypes for 277,301 individuals, leading to the discovery of 18.4% more GWAS loci.

Highly Accurate Non-Invasive Preimplantation Genetic Testing for Monogenic and Polygenic Diseases from Spent Medium

This paper presents a non-invasive preimplantation genetic testing method using spent embryo culture medium, achieving high accuracy for monogenic and polygenic disease detection without modifying IVF workflows.

A Dynamic Genetic Atlas of Gestational Phenotypes

The paper identifies 4,688 genome-wide significant loci for 111 gestational phenotypes and finds dynamic genetic effects linked to maternal health outcomes.

Utilizing Non-Invasive Prenatal Test Sequencing Data Resource for Human Genetic Investigation

The paper develops methods for analyzing low-depth NIPT sequencing data to accurately estimate allele frequencies and genetic effect sizes, enabling population genetic studies.

An Atlas of Linkage Disequilibrium Across Species

The paper introduces two LD estimation algorithms to create high-resolution LD grids across species, revealing evolutionary patterns and population structure.

Genetic study of intrahepatic cholestasis of pregnancy in 101,023 Chinese women unveils East Asian-specific etiology linked to historic HBV infection

This study identifies East Asian-specific genetic loci for intrahepatic cholestasis of pregnancy linked to historical HBV infection, using genome-wide association analyses in 101,023 Chinese women.

The Garden of Forking Paths: Reinterpreting Haseman-Elston Regression for a Genotype-by-Environment Model

This paper reinterprets Haseman-Elston regression to detect genotype-by-environment interactions by analyzing symmetry in linkage and association results.

DeepKin: precise estimation of in-depth relatedness and its application in UK Biobank

deepKin estimates relatedness with statistical inference and applies it to UK Biobank data, identifying significant relatives and geographic patterns.

GWAS of ~30,000 samples with bone mineral density at multiple skeletal sites and its clinical relevance on fracture prediction, genetic correlations and prioritization of drug targets

This study performs GWAS on BMD traits and fracture risk using 30,000 UK Biobank samples, identifies novel loci, and prioritizes drug targets for osteoporosis prevention.

Searching across-cohort relatives in 54,092 GWAS samples via encrypted genotype regression

This paper introduces encG-reg, an encrypted genotype regression method that identifies relatives across cohorts without sharing raw data, achieving accuracy comparable to traditional methods.

BatchServer: a web server for batch effect evaluation, visualization and correction

BatchServer provides a web platform for evaluating, visualizing, and correcting batch effects in omics data using autoComBat, PVCA, and UMAP.