Author

David F. Williams

UK Health Security AgencyORCID 0000-0002-6925-7408Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 2 Organism:bacteria (other)· 1 Approach:benchmark study· 1 Organism:E. coli· 1 Assay:metagenomics· 1 Approach:statistical model· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Nicole E StoesseriD· 2 shared Samuel LipworthiD· 2 shared Alice LeddaiD· 1 shared Ann Sarah WalkeriD· 1 shared Christopher R. JonesiD· 1 shared Colin Stewart BrowniD· 1 shared Derrick W. CrookiD· 1 shared Dorottya NagyiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBioinformatics

Nicole E StoesserORCID

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2 papers

Recent·Most cited

Benchmarking strain-level profiling of Escherichia coli in short-read gut metagenomes

Matthew Galbraith, Williams David, Liam P. Shaw, Samuel Lipworth, Nicole E Stoesser

This study benchmarks six tools for strain-level profiling of E. coli in short-read gut metagenomes, showing significant variation in performance and highlighting StrainR2's high accuracy and PathoScope 2.0/StrainGE's robustness in unknown strain scenarios.

bioRxiv · May 19, 2026 · PreprintBioinformatics

Nanopore long-read only genome assembly of clinical Enterobacterales isolates is complete and accurate

Dorottya Nagy, Valentina Pennetta, Gillian Rodger, Katie M.V. Hopkins, Christopher R. Jones, Susan Hopkins, Derrick W. Crook, Ann Sarah Walker, Julie V. Robotham, Katie L. Hopkins, Alice Ledda, David F. Williams, Russell Hope, Colin Stewart Brown, Nicole E Stoesser, Samuel Lipworth

This study evaluates Nanopore long-read only genome assembly for clinical Enterobacterales isolates, finding Autocycler with Medaka polishing achieves accuracy comparable to hybrid assemblies.

Microbial Genomics · Feb 27, 2026Peer-reviewedBioinformatics