Excitatory drive to spinal motoneurones is necessary for serotonin to modulate motoneurone excitability via 5-HT2 receptors in humans
Tyler T. Henderson, Janet L. Taylor, Jacob R. Thorstensen, Justin J. Kavanagh
This study shows that 5-HT2 receptor antagonism reduces corticospinal and motoneurone excitability during rest and voluntary contractions, but increases cervicomedullary responses only when descending drive is present.
European Journal of Neuroscience · Nov 22, 2023Peer-reviewedNeuroscience