Author

Huiyu Hu

Massachusetts General HospitalORCID 0000-0002-6936-2398Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Approach:deep learning· 1 Approach:experimental assay· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Jeremy M. QuintanaiD· 2 shared Miles Aaron MilleriD· 2 shared Thomas S.C. NgiD· 2 shared Alejandro BertoletiD· 1 shared Arda KönikiD· 1 shared Ayrton Zargani‐Piccardi· 1 shared Chanseo LeeiD· 1 shared Edwina Abou HaidariD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBioengineering

Jeremy M. QuintanaORCID

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2 papers

Recent·Most cited

Enhanced mRNA delivery using ultrasound-delivered click reactive anchors

Emilio Di Ianni, Jueun Jeon, Huiyu Hu, Jeremy M. Quintana, Chanseo Lee, Edwina Abou Haidar, Sedra Mohammadi, Ayrton Zargani‐Piccardi, Mohammed Mahamdeh, Iván Coto Hernández, Thomas S.C. Ng, Koen Breyne, Hakho Lee, Xandra O. Breakefield, Miles Aaron Miller

This paper develops an ultrasound-delivered click reactive anchor strategy to enhance mRNA delivery to extrahepatic tissues, showing improved accumulation and gene expression.

bioRxiv · Jan 28, 2025 · PreprintBioengineering

Localized in vivo prodrug activation using radionuclides

Jeremy M. Quintana, Fangchao Jiang, Mikyung Kang, Víctor Valladolid Onecha, Arda Könik, Lei Qin, Victoria E. Rodriguez, Huiyu Hu, Nicholas Borges, Ishaan Khurana, Leou Ismael Banla, Mariane Le Fur, Peter D. Caravan, Jan Schuemann, Alejandro Bertolet, , Thomas S.C. Ng

This paper demonstrates RAiDER, a method using radionuclides to locally activate prodrugs at tumor sites, showing significant cytotoxicity enhancement and reduced off-target effects.

Journal of Nuclear Medicine · Jan 1, 2025Peer-reviewedBioengineering