ERICH-GENE collects and analyzes genomic and neuroimaging data from over 10,000 multi-ethnic ICH cases to identify genetic risk factors and trans-ethnic variation in ICH.

medRxiv · Jun 11, 2025 · PreprintGenetic & Genomic Medicine

Race- and sex-specific disease trajectory in individuals with rare variants in seven cerebrovascular small vessel disease genes: a genotype-first population study

Jiang Li, Vida Abedi, Durgesh Prasad Chaudhary, Oded Goren, David J. Carey, Karen E. Wain, Ramin Zand

This study identifies race- and sex-specific increased risks of cerebrovascular and circulatory diseases in carriers of seven monogenic CSVD risk genes using a genotype-first approach in a large biobank cohort.

medRxiv · Aug 11, 2022 · PreprintGenetic & Genomic Medicine

MRI Radiomic Signature of White Matter Hyperintensities Is Associated with Clinical Phenotypes

Martin Bretzner, Anna Katharina Bonkhoff, Markus D. Schirmer, Sung‐Min Hong, Adrian Vasile Dalca, Kathleen Donahue, Anne‐Katrin Giese, Mark R. Etherton, Pamela M. Rist, Marco Nardin, Razvan Valentin Marinescu, Clinton J. Wang, Robert William Regenhardt, X. Leclerc, Renaud Lopes, , Natalia S. Rost

This paper develops a radiomic signature from T2-FLAIR MRI images to predict white matter hyperintensities burden and links it to clinical phenotypes.

Frontiers in Neuroscience · Jul 12, 2021Peer-reviewedNeuroscience

Sex-specific lesion topographies explain outcomesafter acute ischemic stroke

Anna Katharina Bonkhoff, Markus D. Schirmer, Martin Bretzner, Sung‐Min Hong, Robert William Regenhardt, Mikael Brudfors, Kathleen Donahue, Marco Nardin, Adrian Vasile Dalca, Anne‐Katrin Giese, Mark R. Etherton, Brandon L. Hancock, Steven J. T. Mocking, Elissa C. McIntosh, John Attia, , Natalia S. Rost

This study identifies sex-specific lesion patterns in acute ischemic stroke that correlate with stroke severity, highlighting differences in lesion distribution between men and women.

bioRxiv · Sep 25, 2020 · PreprintNeuroscience