Quantitative mitochondrial DNA copy number determination using droplet digital PCR with single cell resolution: a focus on aging and cancer
Ryan A. O’Hara, Enzo Tedone, Andrew T. Ludlow, Ejun Elijah Huang, Beatrice Arosio, Daniela Mari, Jerry W. Shay
This paper introduces a ddPCR method to measure mtDNA copy number at single-cell resolution, showing its ability to detect subtle changes in mtDNA content across aging and cancer.
bioRxiv · Mar 16, 2019Molecular Biology