Ryan A. O’Hara

This study creates inducible EWSR1-FLI1 degron alleles in tumor cell lines to control fusion oncoprotein expression, showing reversible cell cycle arrest and tumor growth suppression in xenografts.

This study identifies TASOR's role in maintaining developmental potential during the transition from naive to primed pluripotency by preventing L1 transposable element activation and subsequent cell death.

This study shows H3.3 is important for chromatin accessibility and transcription factor binding at promoters, but not essential for transcription in ESCs, though needed for differentiation.

The paper shows that loss of heterochromatin at ERVs reduces TF binding at euchromatic sites, leading to decreased pluripotency and differentiation.

This study shows ATRX prevents G-quadruplex DNA stress by interacting with the MCM complex and promoting heterochromatin formation via ESET.

This paper introduces a ddPCR method to measure mtDNA copy number at single-cell resolution, showing its ability to detect subtle changes in mtDNA content across aging and cancer.