Functional and morphological alterations of the light perception circuits in postmortem retina from donors at different stages of Alzheimer's disease
Nicolae Sanda, Dan Miléa, Enikò Kövari, Yixin Tong, Talayeh Brügger, Jens Hannibal, Kristof Levente Egervari, Johannes Alexander Lobrinus, Emmanuel Carrera, Gabriele Thumann, Sonja Kleinlogel, Antoine Adamantidis, Ludovic S. Mure
This study examines structural and functional changes in intrinsically photosensitive retinal ganglion cells (ipRGCs) in Alzheimer's disease, finding severe loss and altered function of these cells that may contribute to circadian rhythm disruption.
bioRxiv · Feb 18, 2025 · PreprintNeuroscience