Iván Rodríguez

A spatial single-cell atlas of the claustro-insular region uncovers key regulators of neuronal identity and excitability

This study creates a spatial single-cell atlas of the claustro-insular region in mice, revealing distinct neuronal subtypes and identifying Nr4a2 as a key regulator of neuronal identity and excitability.

The claustrum is critical for maintaining working memory information

This study investigates the role of the claustrum in working memory by analyzing neuronal activity in mice during memory tasks and finds that claustrum inhibition impairs memory performance.

A toolbox for genetic targeting of the claustrum

The paper develops genetic tools to specifically target claustrum neurons in mice, enabling more precise functional studies.

The claustrum drives large-scale interactions of cortical circuits relevant to long-term memory

The paper investigates the role of the claustrum in coordinating inter-areal cortical activity and its impact on memory consolidation and retrieval.

Transcriptional adaptation of sensory neurons to GPCR identity and activity

The paper investigates how olfactory sensory neurons adapt transcriptionally to GPCR identity and activity, finding that receptor-specific transcriptomic profiles change with odorant exposure.

SARS-CoV-2 receptor and entry genes are expressed by sustentacular cells in the human olfactory neuroepithelium

The paper identifies sustentacular cells in the human olfactory neuroepithelium as expressing ACE2 and TMPRSS2, suggesting they may serve as entry points for SARS-CoV-2.

The claustrum-medial prefrontal cortex network controls attentional set-shifting

Claustrum neurons provide direct excitatory input to medial prefrontal cortex pyramidal cells, and inhibiting claustrum neuronal assemblies suppresses prefrontal assembly formation and prevents attentional set-shifting.

Restoring wild type-like network dynamics and behaviour during adulthood in a mouse model of schizophrenia

The paper rescues network dynamics and behaviour in a mouse model of schizophrenia by restoring parvalbumin interneuron excitability.