An IL-21R STAT hypomorph circumvents functional redundancy in germinal center responses
Christoph Jandl, Joanna Warren, Samantha J. Owens, Marcel Batten, Howard Wang, Cecile King
This study identifies an IL-21R hypomorph mutation that specifically impairs STAT1 activation, revealing a nonredundant role for IL-21 in Tfh cell differentiation.
eLife · Oct 23, 2026Peer-reviewedImmunology