Reduction of Neuroinflammation and Seizures in a Mouse Model of CLN1 Batten Disease using the Small Molecule Enzyme Mimetic, N-Tert-Butyl Hydroxylamine.
Zach Fyke, Rachel Johansson, Anna I. Scott, Devin Wiley, Daniel Chelsky, Joseph D. Zak, Nader Al-Nakouzi, Kevin P. Koster, Akira Yoshii
This study shows that NtBuHA reduces neuroinflammation and seizures in a Cln1-/- mouse model of CLN1 Batten Disease.
Molecular Genetics and Metabolism · Jul 15, 2024Peer-reviewedNeuroscience