Ellen Looijesteijn

Feeding-mode-defined microbial communities modulate prebiotic responses and alters colonic motility in early life

This study shows that prebiotic responses depend on feeding mode and microbial community structure, affecting colonic motility through specific metabolic interactions.

Simulations of the infant gut microbiota suggest that complex ecological interactions regulate effects of human milk oligosaccharides on microbial mucin consumption

The paper uses computational simulations to show that human milk oligosaccharides (HMOs) reduce mucin consumption by promoting non-mucin-consuming bacteria over mucin-consuming ones through ecological interactions.

2'-Fucosyllactose helps butyrate producers outgrow competitors in infant gut microbiota simulations

The paper uses a multiscale model to show that 2-FL supports butyrate producers in infant gut simulations by promoting propane-1,2-diol production, which outcompetes other bacteria.

A multiscale spatiotemporal model including a switch from aerobic to anaerobic metabolism reproduces succession in the early infant gut microbiota

The paper develops a multiscale model of infant gut microbiota succession, showing that oxygen levels influence the transition from facultative to strict anaerobes like Bifidobacterium.