Yuchi Qiu

Persistent spectral theory-guided protein engineering

This paper introduces TopFit, a framework that combines persistent spectral theory and sequence embeddings to predict protein fitness from mutations, validated on 34 benchmark datasets.

Multiple morphogens and rapid elongation promote segmental patterning during development

The paper develops a stochastic multiscale cell-based model to study how multiple morphogens and tissue dynamics regulate segment formation in the zebrafish hindbrain.

Feedback control of morphogen gradient scale

The paper investigates how Dpp morphogen gradients scale in Drosophila wing discs and proposes an alternative feedback model to explain scaling failure in mutants.