Author

Akira Ito

Tohoku UniversityORCID 0000-0002-7064-9863Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Organism:human· 1

Frequent Co-Authors

Teresa SáncheziD· 3 shared Costantino IadecolaiD· 2 shared Gab Seok KimiD· 2 shared Giuseppe FaracoiD· 2 shared Hiroki UchidaiD· 2 shared Josef AnratheriD· 2 shared Kuniyasu NiizumaiD· 2 shared Michael KlukiD· 2 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersNeuroscience

Teresa SánchezORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Endothelial Sphingosine-1-Phosphate Receptor (S1PR) 1, a Functional S1PR in the Human Cerebrovascular Endothelium, Limits Blood Brain Barrier Permeability and Neuronal Injury following Subarachnoid Hemorrhage in Mice.

Akira Ito, Hiroki Uchida, Sabyasachi Dash, Daiki Aburakawa, Yuto Shingai, Cathy Liu, Paulo Avila-Gomez, Keita Tominaga, Gab Seok Kim, Giuseppe Faraco, Richard L. Proia, Kuniyasu Niizuma, Teiji Tominaga, Josef Anrather, Costantino Iadecola, , Teresa Sánchez

This study investigates the role of endothelial S1PR1 in maintaining BBB integrity and reducing neuronal injury after subarachnoid hemorrhage in mice and humans.

bioRxiv · Jan 19, 2025 · PreprintNeuroscience

Endothelial sphingosine-1-phosphate receptor 1 deficiency exacerbates brain injury and blood brain barrier dysfunction upon subarachnoid hemorrhage in mice.

Akira Ito, Hiroki Uchida, Gab Seok Kim, Giuseppe Faraco, Richard L. Proia, Kuniyasu Niizuma, Teiji Tominaga, Josef Anrather, Costantino Iadecola, Michael Kluk, Teresa Sánchez

This study shows that endothelial S1PR1 deficiency worsens brain injury and BBB dysfunction in mice after subarachnoid hemorrhage.

bioRxiv · Nov 17, 2019 · PreprintNeuroscience

An optimized method for the isolation and the molecular characterization of cerebral microvessels in vivo

Yun-Kyoung Lee, Helen K. Smith, Hui Yuan, Akira Ito, Teresa Sánchez

This paper presents an optimized method to isolate cerebral microvessels from mouse brains without enzymatic digestion, enabling consistent molecular characterization and analysis of gene expression, DNA methylation, and chromatin structure.

bioRxiv · Jun 13, 2018 · PreprintNeuroscience