Josef Anrather

Intravital pH Imaging using the sensor ApHID Reveals Incomplete Lysosomal Acidification in Resident Meningeal Phagocytes.

The paper uses ApHID-dextran to measure lysosomal pH in mouse meningeal phagocytes, revealing incomplete acidification and changes under pathological conditions.

ABERRANT HIPPOCAMPAL NEUROGENESIS IS A CONSERVED RESPONSE TO STROKE IN MICE: A MULTI-CENTER MULTIMODEL STUDY

This study shows that stroke increases hippocampal neurogenesis but leads to maladaptive morphological features in newborn neurons across multiple mouse stroke models.

Assessing post-stroke cognition in pre-clinical models: lessons and recommendations from a multi-center study

This study evaluates cognitive outcomes after stroke in mice using multiple models and tests, finding inconsistent results and highlighting challenges in pre-clinical stroke cognition research.

Neutrophil stalling does not mediate the increase in tau phosphorylation and the cognitive impairment associated with high salt diet

This study shows that capillary neutrophil stalling contributes to reduced cerebral blood flow in high salt diet but not to tau phosphorylation or cognitive impairment.

Hypertension-Induced Neurovascular and Cognitive Dysfunction at Single-Cell Resolution

This study uses scRNA-seq in a mouse hypertension model to identify early molecular changes in brain cells linked to neurovascular dysfunction and cognitive impairment.

Endothelial Sphingosine-1-Phosphate Receptor (S1PR) 1, a Functional S1PR in the Human Cerebrovascular Endothelium, Limits Blood Brain Barrier Permeability and Neuronal Injury following Subarachnoid Hemorrhage in Mice.

This study investigates the role of endothelial S1PR1 in maintaining BBB integrity and reducing neuronal injury after subarachnoid hemorrhage in mice and humans.

Molecular and functional alterations in the cerebral microvasculature in an optimized mouse model of sepsis-associated cognitive dysfunction.

This study develops and validates a mouse model of sepsis-induced cognitive dysfunction, identifying molecular and functional changes in the cerebral microvasculature and their association with cognitive impairment.

A minimally invasive thrombotic stroke model to study circadian rhythm in awake mice

This paper develops a minimally invasive thrombotic stroke model in mice that allows for reperfusion therapy and in vivo imaging, showing it produces reproducible infarcts and is ameliorated by tPA.

Comparative multi-omics analyses of cardiac mitochondrial stress in three mouse models of frataxin deficiency

The paper compares multi-omics data from three mouse models of partial frataxin deficiency to assess mitochondrial stress in the heart, finding mild transcriptional changes despite severe FXN reduction.

Calcium transients in nNOS neurons underlie distinct phases of the neurovascular response to barrel cortex activation in awake mice

The paper investigates the relationship between nNOS neuron activity and vascular responses in the barrel cortex of awake mice, finding distinct temporal roles for different nNOS neuron subsets in neurovascular coupling.

Meningeal IL-17 producing T cells mediate cognitive impairment in salt-sensitive hypertension

This study identifies meningeal IL-17-producing T cells as a key driver of cognitive impairment in hypertension, showing their role in activating brain macrophages and suggesting therapeutic targets.

A preclinical randomized multicenter trial of anti-IL-17A treatment for acute ischemic stroke

This paper reports a preclinical randomized trial showing that anti-IL-17A treatment reduces infarct volume in a mouse stroke model.

Endothelial sphingosine-1-phosphate receptor 1 deficiency exacerbates brain injury and blood brain barrier dysfunction upon subarachnoid hemorrhage in mice.

This study shows that endothelial S1PR1 deficiency worsens brain injury and BBB dysfunction in mice after subarachnoid hemorrhage.

Dietary salt promotes cognitive impairment through tau phosphorylation

This study shows that a high-salt diet causes cognitive impairment in mice through tau hyperphosphorylation, which is prevented by restoring nitric oxide production.

AGO CLIP reveals an activated network for acute regulation of brain glutamate homeostasis after ischemic stroke

The paper uses AGO CLIP to identify miRNA-target interactions in the brain after ischemic stroke, revealing miR-29 family members lose target regulation, leading to rapid proteomic changes in glutamate homeostasis.

Endogenous protection from ischemic brain injury by preconditioned monocytes

This paper identifies a neuroprotective subpopulation of monocytes induced by lipopolysaccharide preconditioning that reduces brain injury after stroke in mice.