Richard L. Proia

The paper shows pyridoxine supplementation improves SPLIS symptoms in a patient and mouse model by reducing S1P levels and enhancing SPL activity.

This study identifies a pathway involving very-long-chain ceramide synthesis that is essential for 1-deoxysphinganine-induced ER stress and neurotoxicity in SH-SY5Y cells.

This study investigates the role of endothelial S1PR1 in maintaining BBB integrity and reducing neuronal injury after subarachnoid hemorrhage in mice and humans.

This study shows that endothelial-derived sphingolipids are essential for vascular development and systemic lipid homeostasis, with effects on retinal vascularization and liver toxicity.

The paper characterizes S1PR1-regulated transcriptomes in aortic endothelial cells, revealing distinct subtypes and signaling mechanisms in arterial and lymphatic endothelium.

This study shows that endothelial S1PR1 deficiency worsens brain injury and BBB dysfunction in mice after subarachnoid hemorrhage.